A Versatile Approach for Synthesis of Various Pyrimidine Derivatives Clubbed with Pyrazolone Structure and Their Biological Activities

Authors

  • Amish P. Khamar  Arts, Science & R. A. Patel Commerce College, Bhadran, Gujarat, India

Keywords:

Pyrazolopyrimidines, Antitubercular Activity, Antimycobacterial Activity, MABA Assay.

Abstract

Different pyrimidine derivatives clubbed with pyrazolone structure possessing a diversity of substituents in the 6-position have been synthesized and evaluated for Mycobacterium tuberculosis activities. Several compounds demonstrated IC90 ≤ 10 µg/mL and were found to be active against Mycobacterium tuberculosis strain Compound 8d was found to be most active compound in vitro with IC90 of 1.53.

References

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International Journal of Scientific Research in Science and Technology

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Published

2017-02-28

Issue

Volume 3, Issue 1, January-February-2017

Section

Research Articles

License

Copyright (c) IJSRST

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
Amish P. Khamar, " A Versatile Approach for Synthesis of Various Pyrimidine Derivatives Clubbed with Pyrazolone Structure and Their Biological Activities, International Journal of Scientific Research in Science and Technology(IJSRST), Online ISSN : 2395-602X, Print ISSN : 2395-6011, Volume 3, Issue 1, pp.658-665, January-February-2017.