Management of Diabetic Infected Ulcer with Maggot Therapy

Authors

  • Dr. Santosh Shreekant Betgeri Professor & HOD, Department of Shalyatantra, Bhimashankar Ayurved College Hospital & Research Center, Wadgaon Kashimbeg (Walunjwadi) Pune, Maharashtra, India Author

DOI:

https://doi.org/10.32628/IJSRST251318

Keywords:

Diabetic foot ulcer, Maggot Debridement Therapy, Lucilia sericata, Biological debridement, Biofilm, Vrana Chikitsa, Integrative wound care

Abstract

Diabetic foot ulcers (DFUs) are a major complication of diabetes mellitus, often leading to infection, delayed healing, and increased risk of amputation. Conventional treatments may be ineffective due to poor vascularization, antibiotic resistance, and chronic inflammation. Maggot Debridement Therapy (MDT), which uses sterile larvae of Lucilia sericata, has re-emerged as an effective biotherapeutic approach that selectively removes necrotic tissue, decreases bacterial load, and promotes granulation. This case review highlights the successful management of an infected diabetic ulcer with MDT, detailing its mechanisms, clinical outcomes, and integrative potential with modern wound care. Evidence from recent studies supports MDT as a safe, cost-effective, and efficient adjunct to conventional treatments, significantly enhancing healing rates in chronic diabetic wounds.Keywords: Diabetic foot ulcer; Maggot Debridement Therapy; Lucilia sericata; Biological debridement; Biofilm; Vrana Chikitsa; Integrative wound care.

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References

IWGDF/IDSA. IWGDF/IDSA Guidelines on the Diagnosis and Treatment of Diabetes related Foot Infections. 2023 Oct 2. Infectious Diseases Society of America Practice Guidelines. [Online].

Gabrielsen P. How Maggots Heal Wounds. ScienceNOW / Wired. 7 Dec 2012. (Historical overview; FDA clearance context.)

Wang SY et al. Maggot debridement therapy promotes diabetic foot wound healing by up regulating endothelial cell activity. J Surg Res. 2016. PubMed PMID: 26782021.

Akbari A et al. Efficacy of Maggot Therapy on Staphylococcus aureus and Pseudomonas aeruginosa in Diabetic Foot Ulcers: A Randomized Controlled Trial. 2019. PubMed PMID: 30608337.

Cazander G et al. Maggot excretions inhibit biofilm formation on biomaterials. Clin Orthop Relat Res. 2010. PubMed PMID: 20309656. DOI: https://doi.org/10.1007/s11999-010-1309-5

Sherman RA et al. Antimicrobial peptides expressed in medicinal maggots of the blow fly Lucilia sericata show combinatorial activity against bacteria. Antimicrob Agents Chemother. 2015. PMC4394815.

Bulińska D et al. Effectiveness of Chronic Wound Debridement with the Use of Larvae of Lucilia sericata. J Clin Med. 2019;8(11):1845. DOI: https://doi.org/10.3390/jcm8111845

Kendall A et al. Maggots in Medicine: A Narrative Review Discussing the Barriers to Maggot Debridement Therapy and Its Utilisation in the Treatment of Chronic Wounds. J Clin Med. 2023;13(22):6746. DOI: https://doi.org/10.3390/jcm13226746

Use of larvae in the treatment of the diabetic necrotic foot. Diabetic Foot Journal. Diabetesonthenet.com. (Clinical guidance article.)

Biotherapy Medical Co. How to Use BioBag (clinical instruction guide). Accessed 2025.

Singh A et al. Maggot debridement therapy as primary tool to treat chronic wound (animal & translational review). Vet World 2016. PMC4864483.

D’Souza et al. Defensins of Lucilia sericata Larvae and Their Influence on Wound Repair Processes: Practical Assessment—Three Cases. Int J Environ Res Public Health. 2023;20(7):5357. DOI: https://doi.org/10.3390/ijerph20075357

Shindhe PS et al. Integrative management of diabetic foot ulcers – A case series. J Ayurveda Integr Med. 2023;14(5):100770. PMC10692380. DOI: https://doi.org/10.1016/j.jaim.2023.100770

Current scenario of traditional medicines in management of diabetic foot ulcers: A review. World J Diabetes? (check final journal & year; PMC9850800) 2023.

Baslingappa K et al. Management of Madhumehajanya Dusta Vrana with Indigenous Drug Followed by Jalokavacharana. Int J Ayurveda Pharma Res. 2025;13(1):222 226. DOI: https://doi.org/10.47070/ijapr.v13i1.3556

MG P, Sweta KM. Ayurvedic Treatment Principles in the Management of Madhumehajanya Vrana – A Case Study. Int J AYUSH Case Rep. 2023;7(4):431 436.

Charaka Samhita, Chikitsa Sthana 25 (Vrana Chikitsa). Translated summary: EasyAyurveda.com; accessed 2025.

Dwivraniya Chikitsa (Caraka Samhita Online Resource). Accessed 2025.

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Published

19-07-2025

Issue

Section

Research Articles

How to Cite

Management of Diabetic Infected Ulcer with Maggot Therapy. (2025). International Journal of Scientific Research in Science and Technology, 12(4), 540-547. https://doi.org/10.32628/IJSRST251318